Dietary supplementation of coenzyme Q10 plus multivitamins to hamper the ROS mediated cisplatin ototoxicity in humans: A pilot study
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Dietary supplementation of coenzyme Q10 plus multivitamins to hamper the ROS mediated cisplatin ototoxicity in humans: A pilot study
Oxidative stress exerts major role in the pathogenesis of side effects of many antineoplastic drugs, including ototoxicity of cisplatin. In particular, increased levels of reactive oxygen species (ROS) represent one of the molecular mechanisms underlying the apoptosis of different types of hearing cells. Antioxidants and ROS scavengers may thus represent potential therapeutic options to prevent...
متن کاملCoenzyme Q10 plus Multivitamin Treatment Prevents Cisplatin Ototoxicity in Rats
Cisplatin (Cpt) is known to induce a high level of oxidative stress, resulting in an increase of reactive oxygen species damaging the inner ear and causing hearing loss at high frequencies. Studies on animal models show that antioxidants may lower Cpt-induced ototoxicity. The aim of this study is to evaluate the ototoxic effects of two different protocols of Cpt administration in a Sprague-Dawl...
متن کاملCorrection: Coenzyme Q10 plus Multivitamin Treatment Prevents Cisplatin Ototoxicity in Rats
[This corrects the article DOI: 10.1371/journal.pone.0162106.].
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ژورنال
عنوان ژورنال: Heliyon
سال: 2017
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2017.e00251